Comprehensive Assessment of Neurodegeneration and Dementia
This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits. Participants are/will be recruited at sites across Canada and will undergo assessments, neuroimaging, and biological sample collection.
Study identifier: NCT03402919. Status: RECRUITING.
Eligibility
Criteria: Inclusion Criteria: * Has subjective or objective cognitive impairment * Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member) * Sufficient proficiency in English or French to undertake self report and neuropsychological testing * Geographic accessibility to the study site * Must have a study partner who can participate as required in the protocol (provide corroborative information) * Up to 12 years of education * Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment Exclusion Criteria: * The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's cohort), and other rarer brain illnesses * Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures * Symptomatic stroke within the previous year * Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure
- Minimum age: 50 Years
- Maximum age: 90 Years
Participating locations
- University of Calgary, Calgary, Alberta
- University of Alberta Hospital, Edmonton, Alberta
- Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia
- Island Health, Victoria, British Columbia
- Veteran's Memorial Building, Halifax, Nova Scotia
- Hamilton General Hospital, Hamilton, Ontario
- St. Joseph's Health Care London, London, Ontario
- Gait and Brain Lab, London, Ontario
- Bruyère Research Institute, Ottawa, Ontario
- Kawartha Centre, Peterborough, Ontario
Study records are sourced from ClinicalTrials.gov. Confirm current eligibility, recruiting status, and locations in the official record.