Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD
This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment). Assessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions/networks. Correlations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.
Study identifier: NCT07153692. Status: RECRUITING. Phase: NA.
Eligibility
Criteria: Inclusion Criteria: * Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy; * VFSS examination indicates dysphagia; * Mini-Mental State Examination (MMSE) score \>23; * Willing to cooperate with the study and sign the informed consent form; Exclusion Criteria: * Comorbid with other diseases that cause dysphagia; * Comorbid with pneumonia, or severe cardiac/renal insufficiency; * Having metal implants in the body * With cognitive impairment or inability to cooperate.
- Minimum age: 18 Years
- Maximum age: 100 Years
Participating locations
- Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Study records are sourced from ClinicalTrials.gov. Confirm current eligibility, recruiting status, and locations in the official record.