Research Into the Expression of the csgA-gene and How it Changes in Patients With Parkinson's Disease
This study seeks to understand the prevalence and variability of a gut bacteria gene called csgA in people with Parkinson's Disease. This understanding could inform development of potential new therapies targeting the gut in Parkinson's Disease.
Study identifier: NCT07175922. Status: RECRUITING.
Eligibility
Criteria: Inclusion Criteria: * Between 18-80 years of age at ICF signing (inclusive) * A diagnosis of PD within 10 years from the time of ICF signing * Current or history of gastrointestinal (GI) dysfunction or constipation based on screening assessment * All participants must understand and provide written informed consent prior to any study specific procedures * Able to speak, read, and understand study procedures in Dutch sufficiently to allow completion of all study assessments Exclusion Criteria: * Any known GI disorder if deemed clinically significant by the investigator. GI disorders may include, but are not limited to: Crohn's disease, ulcerative colitis, celiac disease, irritable bowel syndrome, or lactose intolerance * Recent GI infection in the past 3 months if deemed clinically significant by the investigator. * Major GI surgery (excluding appendectomy/cholecystectomy), such as bariatric surgery, gastrectomy, esophagectomy, vagotomy, small intestine surgeries, any type of colectomy, colostomy and anorectal surgeries if deemed clinically significant by the investigator * Any known current or past eating disorder if deemed clinically significant by the investigator * Use of systemic antibiotics within 30 days prior to enrollment
- Minimum age: 18 Years
- Maximum age: 80 Years
Participating locations
- Center for Human Drug Research, Leiden
Study records are sourced from ClinicalTrials.gov. Confirm current eligibility, recruiting status, and locations in the official record.